For only the second time ever, scientists believe they’ve cured someone of HIV. The person is only identified as “the London patient.” But a study published in The Lancet on Tuesday details how doctors effectively eliminated the virus.
The key to this possible cure is a gene known as CCR5. Some people have a mutation of CCR5 that is resistant to HIV. The London patient had HIV and a rare form of blood cancer. The patient got a stem cell transplant to treat cancer from a donor who has the HIV-resistant form of the CCR5 gene. The transplant helped treat both cancer and HIV.
A year after the “London Patient” was introduced to the world as only the second person to be cured of H.I.V., he is stepping out of the shadows to reveal his identity. “I want to be an ambassador of hope,” he said. https://t.co/l4XxVgj8AK— The New York Times (@nytimes) March 9, 2020
As part of the study, the London patient stopped taking antiretroviral drugs usually used to combat the virus. That allowed doctors to clearly identify the effects of the stem cell transplant.
Despite stopping the antiretroviral treatment, the London patient has been in HIV remission for 30 months. The study says there are still some low levels of HIV in the patient’s body, but the virus that’s left isn’t capable of self-replicating.
The first patient cleared of HIV using the mutated CCR5 gene, Timothy Brown, has been HIV-negative for 13 years. The success of these two patients is groundbreaking, but that doesn’t mean this is an effective treatment for people whose HIV is well controlled with antiretroviral drugs.
Researchers warn the CCR5 treatment should only be used as a last resort for patients who also have life-threatening blood cancer.
The researchers stressed that such a bone-marrow transplant would not work as standard therapy for all patients with HIV. Such transplants are risky, and both Castillejo and Brown needed the transplants to treat cancer, rather than for HIV.
In the new report, doctors found no active viral infection in Castillejo’s body. However, they did find “remnants” of HIV’s DNA in some cells. But the authors said these traces of DNA can be thought of as “fossils,” because they are unlikely to allow the virus to replicate. Such remnants were also found in Brown’s case.